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Food writer Michael Pollan does not oppose eating genetically modified foods, but expressed concerns about biotechnology companies holding the intellectual property of the foods people depend on, and about the effects of the growing corporatization of large-scale agriculture.

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The dispute involves consumers, farmers, biotechnology companies, governmental regulators, non-governmental organizations, and scientists.The key areas of controversy related to genetically modified food (GM food or GMO food) are whether such food should be labeled, the role of government regulators, the objectivity of scientific research and publication, the effect of genetically modified crops on health and the environment, the effect on pesticide resistance, the impact of such crops for farmers, and the role of the crops in feeding the world population.In addition, products derived from GMO organisms play a role in the production of ethanol fuels and pharmaceuticals.Instead, PABE found that public had "key questions" about GMOs: "Why do we need GMOs? Why are we not given an effective choice about whether or not to buy these products?Have potential long-term and irreversible consequences been seriously evaluated, and by whom?Advocates support mandatory labeling laws for food made from GMOs .

Many protests occurred in Southern California, and some participants carried signs expressing support for mandatory labeling of GMOs that read "Label GMOs, It's Our Right to Know", and "Real Food 4 Real People". Monsanto said that it respected people's rights to express their opinion on the topic, but maintained that its seeds improved agriculture by helping farmers produce more from their land while conserving resources, such as water and energy.

The sentencing judge accused Greenpeace of cynically using junior members to avoid risking their own freedom.

The offenders were given 9-month suspended sentences. Per the Science Moms director, the film "focuses on providing a science and evidence-based counter-narrative to the pseudoscience-based parenting narrative that has cropped up in recent years." There are various conspiracy theories related to the production and sale of genetically modified crops and genetically modified food that have been identified by some commentators such as Michael Shermer.

The same survey found gender differences: 10% of men were extremely concerned, compared with 16% of women, and 16% of women were unconcerned, compared with 27% of men.

A 2013 poll by The New York Times, showed that 93% of Americans wanted labeling of GM food.

include genetic engineering in general as an environmental and political concern.