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Today, Google, Apple, Bosch, Facebook, Uber, Nokia, Autodesk, and IBM are among 1,600 technology firms generating $20.7 billion in annual Pittsburgh payrolls.

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By the terms of the 1768 Treaty of Fort Stanwix, the Penns were allowed to purchase the modern region from the Iroquois.Fort Pitt (now Pittsburgh) at the source of the Ohio River became the main base for settlers moving into the Northwest Territory.The War of 1812 cut off the supply of British goods, stimulating American industry.During Pontiac's Rebellion, native tribes conducted a siege of Fort Pitt for two months until Colonel Henry Bouquet relieved it after the Battle of Bushy Run.Fort Pitt is notable as the site of an early use of smallpox for biological warfare.The following year, the Pittsburgh Post-Gazette was started, and in 1787, the Pittsburgh Academy was chartered.

Unrest during the Whiskey Rebellion of 1794 resulted in federal troops being sent to the area.

General John Forbes finally took the forks in 1758.

Forbes began construction on Fort Pitt, named after William Pitt the Elder while the settlement was named "Pittsborough".

On March 8, 1771 Bedford County, Pennsylvania was created to govern the frontier.

On April 16, 1771, the city's first civilian local government was created as Pitt Township.

By 1797, glass manufacture began, while the population grew to around 1,400.